Cognitive Behavioral Therapy (CBT), Modafinil, or Both for MS Fatigue

Many individuals with MS suffer from fatigue, which can be their most disabling symptom. Research is needed to figure out how to match treatments to individual patients so that the treatments will have the greatest effect. 

The purpose of this clinical trial is to compare the effectiveness of 3 treatments for fatigue in MS: 1) a commonly used behavioral treatment strategy (telephone-based cognitive behavioral therapy (CBT), 2) a commonly used medication (modafinil), and 3) a combination of both therapies. Each participant will receive one of these 3 treatments for a total of 12 weeks.

Throughout the trial, participants will be given several short surveys (online or in person) to assess fatigue, sleep, and other symptoms. Before and after treatment, participants will wear a watch-like device for 7 days to measure symptoms as well as sleep and physical activity.

This study is funded by the Patient-Centered Outcomes Research Institute (PCORI).

Learn more about the COMBO-MS study and other clinical trials online.

Recently, a manuscript discussing the design of the COMBO-MS study was published in Contemporary Clinical Trials.

If you are interested in learning more about the study or finding out if you qualify, you can read a brief summary and complete some screening questions online now. If you have questions or would like to complete screening over the phone, please email us at or give us a call at (206) 598-0501.