study overview

This clinical trial will see if self-hypnosis or mindfulness meditation can help decrease fatigue severity in people with multiple sclerosis (MS). Such findings could help increase treatment options for people with MS.

People with MS often have problems with fatigue that can interfere with other treatments. For some, fatigue is the most debilitating symptom of MS. Unfortunately, available treatments provide inadequate relief. Past research has found that training in self-hypnosis may reduce fatigue for people with MS. Other research showed mindfulness meditation can reduce fatigue in the general population.

What do I have to do?

  • Staff will randomly assign participants to either (1) mindfulness meditation, (2) self-hypnosis or (3) treatment as usual. 
  • Participants will complete four short online surveys to assess feelings of fatigue, sleep quality, and pain intensity.
  • Participants randomized to (1) mindfulness mediation and (2) self-hypnosis will listen to self-directed audio recordings for four weeks and practice the skills taught for six months. 
  • Participants randomized to treatment as usual will not listen to the audio recordings. Instead, they will continue their regular care. Study staff will offer participants the intervention at the end of the treatment period.
  • All study procedures take place online or on the phone — no in-person visits are required.
  • Up to $80 total compensation provided.

To be eligible, one must

  • be 18 years of age or older
  • have MS
  • have chronic fatigue


For more information, contact study staff at or (206) 598-0501.

Study information

Mark Jensen, Ph.D. is the lead investigator of this study, which the National Multiple Sclerosis Society (NMSS) funds. Find additional study detail at