Optimizing detection and prediction of changes in cognitive function in multiple sclerosis

Cognitive dysfunction is one of the most common problems in MS. But, there are major gaps in our knowledge of its natural history, mechanisms, and impacts where it matters most – in the everyday lives of people with MS. Current methods of measuring cognitive function only provide a “snapshot” of cognition and fail to capture its true nature. This study is designed to test new ways of measuring cognitive function in real-world settings in people with MS. It will examine the utility of novel mobile app-based cognitive tests to detect changes in cognitive function, while also collecting data on things such as physical activity, sleep, and fatigue that may impact cognitive function.

Participants in this study will complete one visit followed by 14-day home monitoring period at baseline and then per year for two years. During the home monitoring period, they will wear an activity monitor and use a smartphone device to complete questionnaires and brief thinking tests 4 times per day. We expect the knowledge gained in this study will lead us to new insights about how to measure cognitive functioning in daily life and better ways to improve overall health-related quality of life of people with these conditions.

You may be eligible to participate if you are 18 years of age or older and have been diagnosed with MS.

Study procedures take place both at home and the UW Multiple Sclerosis Rehabilitation & Wellness Research Center.

Participants will be compensated $600 for completing the full study.

The lead investigator of this study is Anna Kratz, PhD, an external collaborator of the UW Multiple Sclerosis Rehabilitation & Wellness Research Center. This study is funded by the National Institutes of Health (NIH).

Additional details about this study are available on

If you are interested in learning more about the study or finding out if you qualify, please email us at or give us a call at (206) 598-0501.